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目的评价新生儿接种乙肝疫苗效果及低/无应答者再免疫效果。方法资料随机选自2013年1月1日-12月31日出生,在湖南省怀化市溆浦县某预防接种门诊接种疫苗的新生儿125名(首针乙肝疫苗接种均为出生医院),按“0、1、6”程序接种3剂酿酒酵母重组乙型肝炎疫苗(初免),对其中低/无应答新生儿分别用酿酒酵母重组乙型肝炎疫苗或CHO细胞重组乙型肝炎疫苗再次接种3剂(再免),评价疫苗接种效果。结果完成3剂酿酒酵母重组乙型肝炎疫苗接种,抗-HBs阳性人数105名(84.00%),低应答13名(10.40%),无应答7名(5.60%);父母HBs Ag呈阳性与出生于乡镇医院新生儿应答率较低,相较于父母HBs Ag呈阴性与出生于县及以上医院新生儿,对比差异有统计学意义(P<0.05)。20名初免后低/无应答者在完成3剂酿酒酵母重组乙型肝炎疫苗或CHO细胞重组乙型肝炎疫苗再免后,正常应答为18名(90.00%),两种疫苗再免1剂后与再免3剂后的抗-HBs浓度显著升高,对比差异有统计学意义(P<0.05)。结论两种重组乙型肝炎疫苗免疫效果较好;父母HBs Ag呈阳性与出生于乡镇基层医院新生儿的应答率较低;低/无应答者再免后能产生有效应答和提高抗-HBs浓度。
Objective To evaluate the effect of neonatal vaccination on hepatitis B vaccine and the effect of re-immunization of low / non-responders. Methods Data were randomly selected from January 1, 2013 to December 31, born in Hupu County, Huainan City, Hunan Province vaccination outpatient vaccination of 125 newborns (the first dose of hepatitis B vaccination are hospital), press “0,1,6 ” program was inoculated with three doses of Saccharomyces cerevisiae recombinant hepatitis B vaccine (primary immunization), respectively, in which low / no response newborns were treated with Saccharomyces cerevisiae recombinant hepatitis B vaccine or CHO cell recombinant hepatitis B vaccine Inoculation 3 (re-exempt), evaluation of vaccination effect. Results Three doses of Saccharomyces cerevisiae recombinant hepatitis B vaccine were vaccinated. There were 105 (84.00%) anti-HBs positive, 13 (10.40%) low and 7 (5.60% The response rate of newborns in township hospitals was lower than that of HBsAg-negative parents and was born in county and above hospitals. The difference was statistically significant (P <0.05). Twenty euthymic post-immunocompromising / non-responders completed the three doses of S. cerevisiae recombinant hepatitis B vaccine or CHO cell recombinant hepatitis B vaccine, with a normal response of 18 (90.00%) and one vaccine The levels of anti-HBs were significantly increased after 3 doses of re-treatment (P <0.05). Conclusions Both recombinant hepatitis B vaccines have a better immunization effect. The positive rate of HBs Ag in parents is lower than that of newborns born in township primary hospitals. After low / non-responders re-immunization, they can produce effective response and raise the anti-HBs concentration .