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为确定硝喹作用于叶酸代谢哪一环节,分别给感染伯氏疟或约氏疟原虫的小鼠灌服不同剂量的硝喹,另一部分感染同种疟原虫的动物在服用同样剂量硝喹的基础上,分别加服对氨苯甲酸、肌注甲酰四氢叶酸钙和肌注叶酸,结果对氨苯甲酸使硝喹的量效曲线右移,CD_(50)明显加大,表明对氨苯甲酸对硝喹的抗疟作用有明显的拮抗作用,甲酰四氢叶酸钙和叶酸对硝喹基本上无拮抗作用。 鉴于对氨苯甲酸能拮抗硝喹的抗疟作用,认为其作用环节可能是与对氨苯甲酸竞争二氢碟酸合成酶。对叶酸代谢过程中的其它环节,本文也进行了讨论。
In order to determine the role of nitroquin in folic acid metabolism, mice infected with berberine or Plasmodium yoelii were dosed with different doses of irinquine, and the other animals infected with the same type of Plasmodium were treated with the same dose of irinquine On the basis of the results, the dose-effect curve of p-aminobenzoic acid was shifted to the right of CDC (50) with the increase of p-aminobenzoate, intramuscular calcium leucovorin and intramuscular folic acid, respectively. Benzoic acid has a significant antagonistic effect on the anti-malarial effect of quinolone. Calcium leucovorin and folic acid have no antagonistic effect on quinolone. Since p-aminobenzoic acid can antagonize the anti-malarial effect of niacin, it is believed that its action may be in competition with p-aminobenzoic acid for BDD. Other aspects of the process of folic acid metabolism are also discussed in this article.