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目的观察金龙胶囊联合同期放化疗对非小细胞肺癌(NSCLC)的近期疗效及毒副作用。方法 64例局部晚期NSCLC患者,随机分为金龙胶囊联合放化疗治疗组32例,单纯放化疗治疗32例为对照组,放射治疗采用常规放疗,剂量5600~6000 cGy,同步化疗采用吉西他滨+顺铂(GP)方案化疗4周期。对照组采用单纯放化疗,治疗组采用同步放化疗联合金龙胶囊治疗。结果放化疗结束1个月,金龙胶囊治疗组患者的CR率和有效率(PR+CR)分别为16.7%、61.1%;对照组患者的CR率和有效率(PR+CR)分别为13.9%、58.3%,近期疗效无差异,治疗组生活质量明显提高,骨髓抑制、放射性肺损伤及放射性食管炎等放化疗毒副反应降低。结论金龙胶囊联合GP方案同步化放疗治疗中晚期肺癌,减轻了放化疗所致的毒副反应,生活质量改善明显,提高了中晚期肺癌的放化疗耐受性,值得在临床上大力推广应用。
Objective To observe the short-term curative effect and side effects of Jinlong Capsule combined with concurrent chemoradiotherapy on non-small cell lung cancer (NSCLC). Methods Sixty-four patients with locally advanced NSCLC were randomly divided into Jinlong capsule combined with radiotherapy and chemotherapy group (n = 32) and radiotherapy and chemotherapy alone group (n = 32). Radiotherapy was performed with conventional radiotherapy at a dose of 5600-6000 cGy. Chemotherapy with gemcitabine plus cisplatin (GP) chemotherapy 4 cycles. The control group received radiotherapy and chemotherapy alone, and the treatment group received concurrent chemoradiotherapy combined with Jinlong Capsule. Results The CR rate and effective rate (PR + CR) of patients treated with Jinlong Capsule were 16.7% and 61.1% respectively one month after the end of radiotherapy and chemotherapy. The CR rate and effective rate (PR + CR) of patients in the control group were 13.9% , 58.3%, no difference in the recent efficacy, the quality of life of the treatment group was significantly improved, bone marrow suppression, radiation-induced lung injury and radioactive esophagitis and other radiotherapy and chemotherapy side effects reduced. Conclusions Jinlong Capsule combined with GP regimen in the treatment of advanced lung cancer with synchronized radiotherapy can reduce the toxic and side effects caused by radiotherapy and chemotherapy, improve the quality of life and improve the tolerance of radiotherapy and chemotherapy in advanced lung cancer. It is worth to be popularized and applied clinically.