论文部分内容阅读
对烯丙基作为核苷糖环上羟基保护基进行了研究．烯丙基可用于核糖羟基的保护，用ＰｄＣｌ２可脱除核苷糖环上烯丙基，保护及脱保护都很简便．ＰｄＣｌ２还可脱除核苷糖环５－ＯＨ常用的保护基对甲氧基三苯甲基及二对甲氧基三苯甲基．控制适当的条件，ＰｄＣｌ２既能够选择性地脱除对甲氧基三苯甲基或二对甲氧基三苯甲基，又可同时脱除保护糖环羟基的烯丙基．
Allyl was studied as a hydroxyl protecting group on the nucleoside sugar ring. Allyl can be used for the protection of ribose hydroxyl, PdCl2 can be used to remove allyl nucleoside ring, protection and deprotection are very simple. PdCl2 can also be used to remove the nucleoside sugar ring 5 ’’ - OH common protective group of methoxy-trityl and two pairs of methoxy trityl. Under suitable conditions, PdCl2 can selectively remove p-methoxytrityl or p-methoxytrityl, and simultaneously remove allyl which protects the hydroxyl of the sugar.