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为探讨药物流产 (药流 )后流血时间延长的原因 ,采用前瞻性研究 ,分析服用米非司酮药物流产的早孕妇女流产前后血清 E2 、P、TNF- α水平 ,并观察蜕膜、绒毛组织形态及其超微结构变化。结果显示 ,药流后流血时间大于 14天者 (异常组 )流产后 2 4小时血清 E2 、P水平明显降低 (P<0 .0 5 ) ,血清 TNF- α水平升高 (P<0 .0 5 ) ;异常组服药前及流产后 2 4小时血清 E2 、P水平均较药流后流血时间小于 14天者 (正常组 )高 (P<0 .0 5 )。服米非司酮 4 8小时蜕膜、绒毛细胞显示凋亡倾向。提示药流后流血时间延长是患者机体多个方面的平衡遭到破坏而造成的
In order to explore the reasons for prolonged bleeding after medical abortion (abortion), the prospective study was conducted to analyze the levels of serum E2, P and TNF-α before and after abortion in pregnant women taking mifepristone abortion and to observe the morphological changes of decidua and chorion And its ultrastructure changes. The results showed that serum E2 and P levels were significantly decreased (P <0.05) and serum TNF-α levels were elevated (P <0.05) at 24 hours after abortion ). The levels of serum E2 and P in the abnormal group before and 24 hours after abortion were significantly higher than those in the normal group (P <0.05) after the bleeding time was less than 14 days. Decoction of mifepristone 48 hours, decidual cells showed apoptotic tendency. Prompt medical abortion after prolonged bleeding in many aspects of the balance of the body has been destroyed and caused