患者,女,44岁,于2012年12月28日突发头痛、恶心、呕吐等症状,就诊于当地医院行头颅CT未见异常,予以镇痛对症治疗,29日开始症状进一步加重,出现失语、反应迟钝,认知障碍,伴肢体无力,活动明显受限,30日行头颅MRI后考虑静脉窦血栓,31日于当地医院行去颅瓣减压术,为防止外伤性癫痫发作,31日术后给予丙戊酸钠0.5 g,ivd qd,同时给予甘露醇脱水、依达拉奉促进脑循环、营养脑神经细胞药物对症支持治疗,共使用16 d;用药前12月30日WBC4.7×10~9·L~(-1),嗜中性粒细胞2.5×10~9·L~(-1)。2013年1月17日当地医院转入我院诊断静脉窦血栓。入院后停用丙戊酸钠静脉给药,继 The patient, female, aged 44, had headache, nausea, vomiting and other symptoms on December 28, 2012. Visits to the local hospital showed no abnormalities in head CT. Analgesic and symptomatic treatment were given. On the 29th, the symptoms further aggravated and aphasia appeared , Unresponsiveness, cognitive impairment, with limb weakness, activity was significantly limited, on the 30th line cephalic MRI consider venous sinus thrombosis, local hospital on the 31st to cranial flap decompression, to prevent traumatic seizures, on the 31st After administration of sodium valproate 0.5 g, ivd qd, while giving mannitol dehydration, edaravone promote cerebral circulation, nutrition, neuroblasts drug symptomatic and supportive treatment, a total of 16 d; medication before December 30 WBC4.7 × 10 ~ 9 · L ~ (-1), neutrophil 2.5 × 10 ~ 9 · L ~ (-1). January 17, 2013 local hospital transferred to our hospital for diagnosis of sinus thrombosis. After discontinuation of sodium valproate intravenously, following