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Rhatannin(乐丹宁)是日本九州大学西罔五夫教授等人从中国产的大黄(雅黄)中分离提纯的一种新的活性成分。随后大浦彦吉等人又进一步研究了其生化药理学的作用机制,初步阐明了其作用机理。单味中药大黄有泻下、清热、抗菌等方面的药理作用。作者基于对大黄水提液所做的基础研究工作,发现大黄水提液对血尿素氮(BUN)有影响。对实验性肾功能不全动物病理模型有改善作用,故着重研究了Rhatannin对机体氮代谢的影响。尿素在肝、肾中合成。氨基酸代谢中所产生的氨具有毒性,经肝、肾将其转变成无
Rhatannin (Letannin) is a new active ingredient isolated and purified from the rhubarb (Yahuang) produced in China by professors from the University of Kyushu, Japan. Subsequently, Daisuke Okura and others further studied the mechanism of action of its biochemical pharmacology and preliminary elucidated its mechanism of action. Rhubarb has the pharmacological effects of diarrhea, heat, and antibacterial. Based on the basic research done on the extract of rhubarb water, the authors found that extracts of rhubarb have an effect on blood urea nitrogen (BUN). The improvement of animal pathological models of experimental renal insufficiency has focused on the effects of Rhatannin on nitrogen metabolism in the body. Urea is synthesized in the liver and kidneys. The ammonia produced in the metabolism of amino acids is toxic, and it is converted into none by the liver and kidneys.