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再灌注损伤挽救激酶(reperfusion injury salvage kinase,RISK)信号通路是指一组促存活蛋白激酶,主要包括磷脂酰肌醇-3激酶(phosphatidylinositol-3-OHkinase,PI3K)-蛋白激酶B(Akt)和细胞外信号调节蛋白激酶1/2(extra-cellular sig-nal-regulated protein kinase 1/2,Erk1/2),心肌再灌注时被激活,有强大的心脏保护作用。机械干预(如缺血预适应和缺血后处理)和药物干预(如他汀,腺苷,心房钠尿肽等)均能激活RISK信号通路,使心肌梗死面积减少最多达50%。RISK信号通路是近年来研究较多的再灌注时干预的靶点,具有良好的应用前景。文中就RISK信号通路的定义、下游效应器以及作用于RISK信号通路的各种干预方法做一综述。
Reperfusion injury salvage kinase (RISK) signaling pathway refers to a group of pro-survival protein kinase, including phosphatidylinositol-3-OHkinase (PI3K) - protein kinase B (Akt) Extra-cellular sig-nal-regulated protein kinase 1/2 (Erk1 / 2) is activated during myocardial reperfusion and has a strong cardioprotective effect. Mechanical intervention (such as ischemic preconditioning and ischemic postconditioning) and drug intervention (such as statins, adenosine, atrial natriuretic peptide, etc.) activate the RISK signaling pathway to reduce infarct size by up to 50%. RISK signaling pathway in recent years more research intervention target when reperfusion, has a good prospect. This article reviews the definition of RISK signaling pathway, downstream effectors, and various interventions that act on RISK signaling pathways.