调钙素(Calmodulin)是一种广泛存在于真核细胞生物之中的钙结合蛋白,钙离子(Ca~(2+))的许多重要生理调节功能都是通过它来实现的。当细胞受刺激后,细胞内Ca~(2+)浓度增加,于是调钙素与Ca~(2+)结合,使其分子的构象改变,从而能与靶蛋白(酶)相互作用,把酶激活,启动生理反应,例如引起平滑肌的收缩。Cheung和Kakiuchi最先确定调钙素为中心和脑的环核苷酸磷酸二酯酶的Ca~(2+)依赖性激活因子。其后又发现调 Calmodulin is a calcium-binding protein widely found in eukaryotic cells. Many important physiological regulatory functions of calcium ion (Ca 2+) are realized through it. When the cells are stimulated, the intracellular Ca2 + concentration increases, so the combination of calcitonin and Ca2 +, the molecular conformational changes, which can interact with the target protein (enzyme), the enzyme Activate, initiate a physiological reaction, for example, causing smooth muscle contraction. Cheung and Kakiuchi first identified calcitonin-centered and brain cyclic nucleotide phosphodiesterase Ca2 + -dependent activators. Later found again tune