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本实验分别给予100例肾移植术后患者预防性应用抗胸腺淋巴细胞球蛋白(ATG)和100例肾移植术后常规应用环孢素 A(CsA)组进行了持续三个月的临床研究。结果表明:应用ATG 组肾功能恢复快(3～10天。CsA 组7～15天);急性排斥率低(ATG 组18%,CsA 为47%);肾中毒 ATG 组无,而 CsA 组15例(P<0.001),有显著差别;肝中毒及感染发生率无显著差别(P>0.05)。在应用 ATG 过程中同时测定了血清 IL-6、SIL-2R 活性,结果 ATG 组较 CsA 组明显升高。本文还对 ATG 与 CsA、IL-6、SIL-2R 关系以及 ATG 对移植后预防价值进行讨论。
In this study, 100 patients with renal transplantation were treated with prophylactic use of anti-thymocyte lymphocyte globulin (ATG) and 100 cases of routine renal transplantation after cyclosporine A (CsA) group for a continuous three-month clinical study. The results showed that the renal function recovered rapidly in ATG group (3 to 10 days, 7 to 15 days in CsA group), acute rejection rate (18% in ATG group and 47% in CsA group), no renal ATG group, Cases (P <0.001), there was a significant difference; no significant difference in the incidence of liver toxicity and infection (P> 0.05). Serum levels of IL-6 and SIL-2R were measured simultaneously with ATG. The results showed that ATG group was significantly higher than CsA group. This article also discusses the relationship between ATG and CsA, IL-6, SIL-2R and ATG on the prevention value after transplantation.