论文部分内容阅读
目的 观察饮水型氟骨症患者尿中骨吸收代谢产物的改变及其相互间的关系。方法 采用氯胺T法测定氟病区 67名氟骨症患者以及非病区 2 5名对照者的尿中羟脯氨酸含量 ,氟离子选择电极法测定尿氟 ,等离子体光谱仪测定尿中钙、磷、镁、锌含量 ,并均以尿肌酐进行校正。结果 各组之间尿钙、磷、镁、锌、HOP/Cr含量均无差异性 (P >0 .0 5 ) ,各组之间尿氟含量有差异性 (P <0 .0 1)。 4个组的尿F与尿Mg之间 ,尿Ca与尿Mg之间均有正相关关系 (P <0 .0 5 ) ;对照组、轻度组、中度组的尿F与尿Ca之间有正相关关系 (P <0 .0 5 )。中度组的尿HOP/Cr与尿Ca之间 ,尿HOP/Cr与尿P之间有正相关关系 (P <0 .0 5 )。结论 高氟所致的骨吸收代谢紊乱是不容忽视的 ,并且脱离高氟后不能完全恢复 ;氟骨症患者尿氟与骨矿物质代谢以及胶原降解有一定的关系。
Objective To observe the changes of urinary bone resorption metabolites in drinking-type skeletal fluorosis patients and their relationship with each other. Methods The urinary hydroxyproline content in 67 fluorosis patients and non-disease patients in 25 non-endemic area were determined by chloramine T method. Urinary fluoride was measured by fluoride ion selective electrode method. Urinary calcium , Phosphorus, magnesium, zinc, and urine creatinine were corrected. Results The contents of urinary calcium, phosphorus, magnesium, zinc and HOP / Cr in each group had no difference (P> 0.05), and the urinary fluoride content in each group was different (P <0.01). There was a positive correlation between urine F and urinary Mg, urinary Ca and urinary Mg in the four groups (P <0.05). Urinary F and urinary Ca in the control group, mild group and moderate group There was a positive correlation (P <0.05). There was a positive correlation between urinary HOP / Cr and urinary P in urine of HOP / Cr and urine Ca in moderate group (P <0.05). Conclusions The disorder of bone resorption and metabolism caused by high fluoride can not be neglected, and can not be completely recovered after being freed of high fluoride. Urinary fluoride is related to bone mineral metabolism and collagen degradation in patients with skeletal fluorosis.