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目的 观察不同碘营养水平母鼠生育的仔鼠甲状腺形态、大脑重量及脑组织中蛋白质、DNA、RNA含量变化及锌对其的影响作用。方法 应用缺碘饲料喂养Wistar雌性大鼠复制缺碘动物模型 ,同时设补碘、补复合锌和葡萄糖酸锌、补碘加复合锌等组。 3个月时将动物模型进行交配繁育仔鼠 ,1个月后处死仔鼠 ,取垂体、甲状腺进行病理学检查 ,生物化学方法检测大脑组织中蛋白质、DNA、RNA含量。结果 缺碘组大鼠生育的仔鼠体重增长缓慢 ,甲状腺肿大 ,大脑重量减轻 ,脑中蛋白质、DNA、RNA含量降低 ,同时RNA/DNA比值和蛋白质 /DNA比值降低。补锌组的仔鼠甲状腺肿大程度较缺碘组减轻 ,体重增加 ,脑蛋白质、DNA、RNA含量和RNA/DNA、蛋白质 /DNA比值升高。结论 原代缺碘大鼠补锌 ,降低其生育的仔鼠甲状腺肿大程度 ,使大脑蛋白质、DNA、RNA含量增加 ,拮抗缺碘所致的脑发育障碍。
Objective To observe thyroid morphology, brain weight and protein, DNA and RNA content in brain tissue in offspring of offspring with different levels of iodine nutrition and the effect of zinc on them. Methods Iodine-deficient diet was used to feed iodine-deficient animal model of female Wistar rats. At the same time, iodine supplement, zinc supplement and zinc gluconate, iodine supplementation and zinc complexation were set up. At 3 months, the animal model was bred and pups were sacrificed. After 1 month, the pups were sacrificed and the pituitary gland and thyroid gland were taken for pathological examination. The contents of protein, DNA and RNA in brain tissue were detected by biochemical methods. Results The pups born in iodine deficiency group had slow weight gain, goiter and brain weight loss. The content of protein, DNA and RNA in the brain decreased, while RNA / DNA ratio and protein / DNA ratio decreased. The goiter in zinc supplementation group was more severe than that in iodine deficiency group, and the body weight, brain protein, DNA, RNA content and RNA / DNA, protein / DNA ratio increased. Conclusion Primary iodine-deficient rats can increase the content of protein, DNA and RNA in brain, and antagonize the retardation of brain development caused by iodine deficiency.