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树突状细胞(DC)是体内最重要的抗原递呈细胞(APC),具有摄取、处理和提呈抗原至T细胞的功能。DC通过其模式识别受体(PRR)能够识别区分不同类别的病原体,PRR与病原相关分子模式(PAMP)相结合,诱导适应性免疫反应。DC表达的PRR主要包括:Toll样受体(TLR)、C型凝集素受体(CLRs)、NOD样受体(NLR)等。这些受体可以通过启动信号转导通路参与免疫调节。现就DC参与免疫调节的主要相关受体及其介导的信号转导通路研究进展进行综述。
Dendritic cells (DCs) are the most important antigen-presenting cells (APCs) in the body and have the function of uptake, handling and presentation of antigens to T cells. DCs recognize different classes of pathogens through their pattern recognition receptors (PRRs). PRRs bind to pathogen-associated molecular patterns (PAMPs) and induce adaptive immune responses. PRR expressed by DCs mainly include Toll-like receptors (TLRs), C-type lectin receptors (CLRs), NOD-like receptors (NLRs) and the like. These receptors can participate in immunomodulation by activating signal transduction pathways. The research progress on the major related receptors involved in immune regulation and their signal transduction pathways is reviewed.