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不少血清流行病学研究表明,HBV感染与原发性肝细胞癌(HCC)有关。HCC发生率在HBV感染流行区明显高于其他地区,说明HBV在人肝癌的发生方面可能是起主要作用的病因。应用Southern转移杂交技术,证明病毒携带者的HCC,HBV可整合到癌细胞DNA,其频率很高。本文报道一例四岁男童HCC,伴有HBV-DNA整合,并有典型的HBV集积家庭所见的HBV抗原血症。在具有HBV-DNA整合的HCC中,本例乃最年幼患者,而且使我们对病毒在宿主细胞进行整合的时相及其在人肝癌发生的意义有更良好的了解。病例报告:男童,四岁十个月,先前健康,无输血史,主诉咳嗽和腹部变硬。在右肋缘中线下11c m可触及肝脏。入院时肝功能检
A number of sero-epidemiological studies have shown that HBV infection is associated with primary hepatocellular carcinoma (HCC). The incidence of HCC is significantly higher than that of other regions in the prevalence of HBV infection, indicating that HBV may play a major role in the occurrence of human liver cancer. The Southern transfer hybridization technique was used to prove that HCC of the carriers of the virus, HBV can be integrated into the DNA of cancer cells, and its frequency is high. This article reports a 4-year-old boy with HCC, with HBV-DNA integration and typical HBV antigenemia seen in HBV-accumulating families. Among the HCCs with HBV-DNA integration, this case is the youngest patient, and it gives us a better understanding of the timing of the integration of the virus in the host cell and its significance in the development of human liver cancer. Case report: Boy, aged four to ten months, previously healthy, had no history of blood transfusion, complained of coughing and hardened abdomen. In the right costal margin, 11c m can reach the liver. Liver function test on admission