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目的:探讨氯化铵甘草口服溶液不良反应的特点,为临床安全用药提供参考。方法:对本院2014年1月~2016年3月上报的6例氯化铵甘草口服溶液不良反应监测报告进行回顾性分析,对6例患者的年龄、性别、原患疾病,药物使用情况,ADR发生时间、临床表现、治疗与转归,ADR的类型与关联性评价等项目进行统计分析。结果:氯化铵甘草口服溶液不良反应多发生于老年患者;发生时间主要在用药8h内;以累及系统呼吸系统和皮肤为主;6例患者均痊愈,未出现后遗症或导致死亡。6例ADR中一般的ADR 2例,新的一般的ADR 2例,新的严重ADR 2例;关联性评价为可能4例,很可能2例。结论:临床上应重视氯化铵甘草口服溶液的不良反应,应密切观察患者,保证用药安全。
Objective: To investigate the characteristics of adverse reactions of ammonium chloride licorice oral solution and provide references for clinical safety medication. Methods: A retrospective analysis was made on the surveillance reports of adverse reactions of 6 cases of oral administration of ammonium chloride licorice reported from January 2014 to March 2016 in our hospital. The data of 6 patients including age, gender, original disease, drug use, ADR occurrence time, clinical manifestations, treatment and outcome, type of ADR and relevance evaluation projects such as statistical analysis. Results: The adverse reactions of oral solution of ammonium chloride licorice occurred mostly in elderly patients; the time of occurrence was mainly within 8h after treatment; the main respiratory system and skin were involved; all 6 patients were cured without sequelae or death. 6 cases of ADR general ADR 2 cases, the new general ADR 2 cases, new serious ADR 2 cases; correlation was evaluated as possible in 4 cases, most likely in 2 cases. Conclusions: Adverse reactions of oral solution of ammonium chloride licorice should be taken seriously in clinical practice. Patients should be closely observed to ensure drug safety.