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目的 :观察国产去甲长春花碱 (盖诺 )与顺铂治疗晚期非小细胞肺癌的疗效及毒副反应。方法 :共治疗 36例病人 ,盖诺 2 5mg/m2 静滴第 1、8天 ,顺铂 90mg/m2 分 3天 (第 1～ 3天 )静滴。 3周为 1周期 ,化疗 2周期后评价疗效 ,化疗期间记录毒副反应。结果 :CR 0例 ,PR 16例 ,SD 16例 ,PD 4例 ,有效率 4 4 4 % ;毒副反应主要为白细胞减少、恶心呕吐及静脉炎。结论 :盖诺与顺铂治疗晚期非小细胞肺癌疗效确切 ,毒副反应易于耐受 ,可作为晚期非小细胞肺癌的首选方案。
Objective: To observe the curative effect and toxicity of domestic vinorelbine (Gano) and cisplatin in the treatment of advanced non-small cell lung cancer. Methods: A total of 36 patients were treated with intravenous infusion of Gentamycin 25mg / m2 for days 1 and 8 and cisplatin 90mg / m2 for 3 days (days 1 to 3). 3 weeks for 1 cycle, 2 weeks after chemotherapy to evaluate the efficacy of chemotherapy during the record side effects. Results: 0 cases of CR, 16 cases of PR, 16 cases of SD, 4 cases of PD, the effective rate of 444%; side effects mainly leukopenia, nausea and vomiting and phlebitis. Conclusion: Ginow and cisplatin in the treatment of advanced non-small cell lung cancer have definite curative effect and the side effects are easy to tolerate, which may be the first choice for advanced non-small cell lung cancer.