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目的分析肝硬化并发自发性腹膜炎腹水培养的病原菌及耐药性。方法回顾分析287例肝硬化并发自发性腹膜炎患者临床资料,对其腹水病原菌进行培养,实施药敏试验,分析患者耐药性。结果 287例患者经腹水病原菌培养阳性率为13.9%,检测细菌41株,主要为革兰阴性菌、革兰阳性菌及真菌。大肠埃希菌、克雷伯菌和肠杆菌属对美罗培南、亚胺培南、舒普深及阿米卡星的耐药性不超过30%;铜绿假单胞菌和不动杆菌对阿米卡星的耐药性最低。所有革兰阳性菌对万古霉素和利耐唑胺耐药性最低。结论通过对肝硬化并发自发性腹膜炎腹水病原菌培养,掌握致病菌,了解耐药性,为抗菌药选择提供必要参考依据。
Objective To analyze the pathogens and drug resistance of cirrhosis complicated with spontaneous peritonitis in ascites culture. Methods The clinical data of 287 patients with cirrhosis complicated with spontaneous peritonitis were retrospectively analyzed. The ascites pathogens were cultured and drug susceptibility tests were performed to analyze the drug resistance of patients. Results The positive rate of ascites pathogens culture in 287 patients was 13.9%, 41 bacteria were detected, mainly gram-negative bacteria, gram-positive bacteria and fungi. Escherichia coli, Klebsiella and Enterobacter are not more than 30% resistant to meropenem, imipenem, shuxunshen and amikacin; Pseudomonas aeruginosa and Acinetobacter a Mika Star has the lowest drug resistance. All Gram-positive bacteria have the lowest resistance to vancomycin and linacline. Conclusion Through the cirrhosis complicated with spontaneous peritonitis ascites pathogen culture, grasp the pathogens, understand the drug resistance, provide the necessary reference for the choice of antimicrobial agents.