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目的:探讨血清IL~(-1)7和IL-35在心衰患者中的临床价值。方法:选取心衰患者(心衰组)及健康体检者(对照组)各120例,进行分析。结果:心衰组在急性期IL~(-1)7高于稳定期及对照组(P<0.05);在稳定期IL~(-1)7水平降低,但仍然比对照组要高(P<0.05);心衰组在急性期IL-35低于稳定期及对照组;在稳定期IL-35水平升高,但仍然比对照组要低;血清IL~(-1)7和IL-35具有负相关关系(r=-0.483,P<0.05);心衰患者急性期血清IL~(-1)7和射血分数(EF)具有负相关关系(r=-0.642,P<0.05),和心功能分级具有正相关关系(r=0.520,P<0.05);心衰患者急性期血清IL-35和EF具有正相关关系(r=0.528,P<0.05),和心功能分级具有负相关关系(r=-0.635,P<0.05)。结论:定期监测血清IL~(-1)7、IL-35水平有助于心衰的早期发现,并可以对心衰的预后进行评估。
Objective: To investigate the clinical value of serum IL-7 and IL-35 in patients with heart failure. Methods: 120 patients with heart failure (heart failure group) and healthy subjects (control group) were selected and analyzed. Results: The level of IL - 1 in heart failure group was higher than that in stable group and control group (P <0.05), while the level of IL - (-1) 7 in stable group was lower than that of control group (P <0.05). The level of IL-35 in the heart failure group was lower than that in the stationary phase and the control group in the acute phase, while the level of IL-35 in the stable phase was higher than that in the control group. The levels of IL- (R = -0.483, P <0.05). There was a negative correlation between serum IL-7 7 and ejection fraction (EF) in patients with heart failure (r = -0.642, (R = 0.520, P <0.05). There was a positive correlation between serum IL-35 and EF in acute heart failure patients (r = 0.528, P <0.05), and heart function grading was negative Correlation (r = -0.635, P <0.05). CONCLUSION: Regular monitoring of serum levels of IL-7, IL-35 contributes to the early detection of heart failure and can assess the prognosis of heart failure.