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儿童自身免疫性粒细胞减少症(AIN)可以分为两种类型。原发性AIN常表现为单一的中性粒细胞计数少于0.5×10~9/L和中度感染,该病多发生于幼儿,是一种自限性疾病。继发性AIN常表现为重度反复感染。作者分析了28例小儿科AIN患者的临床和血清学资料,以评估中性粒细胞特异性抗体与临床病因的关系。循环中的粒细胞特异性抗体采用粒细胞间接免疫荧光法(GIFT)检测,标准表现型细胞来自献血者。样本进一步用单克隆抗体固定粒细胞抗原方法(MAIGA)确定NA1、NA2、
Children with autoimmune neutropenia (AIN) can be divided into two types. Primary AIN usually presents as a single neutrophil count less than 0.5 × 10 ~ 9 / L and moderate infection, the disease occurs in young children, is a self-limiting disease. Secondary AIN often showed severe repeated infections. The authors analyzed clinical and serological data from 28 pediatric AIN patients to assess the association of neutrophil-specific antibodies with clinical etiology. The circulating granulocyte specific antibodies were detected using the GIFT and the standard phenotypic cells were from donors. Samples were further identified by the monoclonal antibody immobilized leukocyte antigen method (MAIGA) NA1, NA2,