论文部分内容阅读
本文对内源性一氧化氮（NO）、一氧化碳（CO）在感染性休克中的作用了进行了实验研究。结果表明：感染性休克时NO水平于绿脓杆菌注射后6小时显著增高，12小时达到峰值（P＜0．0）。运用NO抑制剂美蓝或／和地塞米松于感染性休克模型，显示可显著降低病死良（P＜0．05）。且与NO显著相关（P＜0．05）。提示NO与CO可能作为内源性介质参与感染性休克的发生发展过程。
In this paper, the role of endogenous nitric oxide (NO) and carbon monoxide (CO) in septic shock was studied. The results showed that during septic shock, the level of NO was significantly increased at 6 hours after Pseudomonas aeruginosa injection, reaching the peak at 12 hours (P <0.0). The use of NO inhibitors methylene blue and / or dexamethasone in septic shock models showed a significant reduction in morbidity (P <0.05). And significantly correlated with NO (P <0.05). It is suggested that NO and CO may participate in the process of septic shock as endogenous mediators.