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目的:探讨血必净注射液对创伤弧菌脓毒症患者凝血机制的影响。方法:将40例创伤弧茵脓毒症患者随机分为2组各20例,对照组行常规治疗,观察组在对照组基础上给予血必净注射液治疗,对2组治疗前后凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)及活化部分凝血活酶时间(APTT)、血小板计数(BPC)、平均血小板体积(MPV)及弥散性血管内凝血(DIC)发生率进行比较。结果:观察组治疗后DIC发生率5%,对照组为30%,2组比较,差异有显著性意义(P<0.05)。与治疗前比较,2组治疗后BPC水平明显上升,差异均有显著性意义(P<0.05)。2组治疗后BPC、MPV比较,差异均有显著性意义(P<0.05)。与治疗前比较,2组治疗后PT、TT、APTT明显减少,FIB明显增多,差异均有显著性意义(P<0.05)。观察组和对照组治疗后TT、APlT、FIB比较,差异均有显著性意义(P<0.05)。结论:血必净注射液能有效改善创伤弧菌脓毒症患者凝血功能及高凝状态,有利于预后。
Objective: To investigate the effect of Xuebijing injection on coagulation mechanism in patients with Vibrio vulnificus sepsis. Methods: Forty cases of patients with arc-wound sepsis were randomly divided into two groups of 20 patients. The control group was treated routinely. The observation group was treated with Xuebijing injection on the basis of the control group. The levels of prothrombin Time, PT, FIB, APTT, BPC, MPV and DIC were measured. The incidence is compared. Results: The incidence of DIC in the observation group after treatment was 5% and that in the control group was 30%. There was significant difference between the two groups (P <0.05). Compared with before treatment, BPC levels in both groups increased significantly after treatment, the differences were significant (P <0.05). The differences of BPC and MPV between the two groups after treatment were significant (P <0.05). Compared with those before treatment, PT, TT and APTT were significantly decreased and FIB was significantly increased after treatment in both groups (P <0.05). The difference of TT, APlT and FIB in observation group and control group after treatment was significant (P <0.05). Conclusion: Xuebijing injection can effectively improve coagulation and hypercoagulability in patients with Vibrio vulnificus sepsis, which is good for prognosis.