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目的探讨听力对噪声敏感者与不敏感者在DNA水平是否存在差异.方法按病例?对照的研究设计在噪声作业工人中收集典型的听力对噪声敏感者与不敏感者,采用随机扩增多态DNA(RAPD)指纹图技术分析DNA的多态性,观察DNA多态性在两组间分布的差异.结果19名敏感工人与20名不敏感工人的年龄、性别、噪声暴露水平和噪声作业工龄均衡,而敏感组工人的听力改变明显高于不敏感组.敏感组工人800BP的RAPD扩增片段阳性出现的频率(18/19)明显高于不敏感组(13/20),P＜0?05,而1000BPRAPD扩增片段的阳性分布频率在两组间无显著差异(14/19VS18/20).结论噪声敏感个体和不敏感个体的DNA存在差异,RAPD是寻找这种差异的途径之一.“,”Object To investigate the difference of DNA between the workers with super sensitive and non sensitive hearing to noise exposure.Method A case control study was applied in the workers whose hearing were typically super sensitive to noise exposure or nonsensitive to noise exposure.Randomly amplified polymorphic DNA(RAPD) anolysis was used to observe the distribution of RAPD in these two groups.Nineteen super sensitive workers and twenty non sen...