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本文报道了一例患头癣和颈淋巴结核的儿童因使用酮康唑抗真菌疗法和同时并用抗结核药物利福平及异烟肼而导致治疗失败。有关详细的临床资料可参考原始文献。现将研究结果综述如下: ·无论是两药同时并用或间隔12小时分别给药,利福平均可导致酮康唑的血浆浓度明显降低。·无论是两药同时并用或间隔12小时分别给药,异烟肼对酮康唑血浆浓度的影响更明显。
This article reports the treatment failure of a child with tinea capitis and cervical lymph node tuberculosis as a result of ketoconazole antifungal therapy and concurrent use of the anti-tuberculosis drugs rifampicin and isoniazid. For detailed clinical information can refer to the original literature. The results of this review are summarized as follows: · Whether the two drugs are given concurrently or with an interval of 12 hours, the average daily dose of rifabutol results in a significant reduction in plasma concentrations of ketoconazole. Isoniazid has a more pronounced effect on the plasma concentration of ketoconazole, irrespective of whether the two drugs are administered simultaneously or separately for 12 hours.