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肺纤维化的主要病理改变为肺成纤维细胞 (ＬＦ)聚积和细胞外基质 (ＥＣＭ)积聚。ＬＦ在肺纤维化过程中有着重要的作用。ＬＦ几乎能合成全部有ＥＣＭ降解活性的基质金属蛋白酶 (ＭＭＰｓ)及其抑制剂 (ＴＩＭＰｓ) ,特别是ＴＩＭＰ 1 [1 ] ,当ＬＦ在静止状态下只能合成较低水平的
The major pathological changes of pulmonary fibrosis are lung fibroblast (LF) accumulation and extracellular matrix (ECM) accumulation. LF plays an important role in pulmonary fibrosis. LF synthesizes almost all matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) with ECM-degrading activity, especially TIMP-1 [1], and LF can only synthesize lower levels of