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目的评估炎性肠病患者使用硫唑嘌呤后因不良反应引起停药的比例及原因。方法对1995至2005年期间北京协和医院和中日友好医院住院病例中使用硫唑嘌呤的31例炎性肠病患者进行回顾性分析。结果7例患者因为出现不良反应而终止治疗,其中6例(19.4%)不良反应发生在用药4周内。结论早期不良反应是引起炎性肠病患者停止硫唑嘌呤治疗的主要原因。
Objective To assess the proportion and causes of discontinuation due to adverse reactions in patients with inflammatory bowel disease after using azathioprine. Methods A retrospective analysis of 31 patients with inflammatory bowel disease using azathioprine in inpatients at Peking Union Medical College Hospital and Sino-Japanese Friendship Hospital from 1995 to 2005 was conducted. Results Seven patients discontinued treatment due to adverse reactions, of which 6 (19.4%) had adverse reactions within 4 weeks of treatment. Conclusions Early adverse reactions are the main reason for stopping azathioprine treatment in patients with inflammatory bowel disease.