485例上海和美国旧金山中国人中6个基因(或基因区)的限制性内切酶片段长度多态性(RFLP)与非胰岛素依赖型糖尿病(NIDDM)的关联情况研究见到:(1)胰岛素受体(INSR)、载脂蛋白B(Apo B)、载脂蛋白A1(Apo A1)3个基因与中国人NIDDM发病有一定关联;(2)RFLP频率有明显的种族间差异,而且同一种民族在不同地区人群中亦有差异;(3)RFLP摹因型对糖尿病的临床表现型有影响,糖尿病与非糖尿病的肥胖在病因学上并不相同,尚见到NIDDM伴脂质代谢紊乱。 485 cases Shanghai and San Francisco, China Chinese 6 people (or gene region) restriction fragment length polymorphism (RFLP) and non-insulin-dependent diabetes mellitus (NIDDM) association studies are as follows: (1) INSR, Apo B and Apo A1 were associated with the pathogenesis of NIDDM in Chinese. (2) The frequency of RFLP was significantly different among races, and the same Ethnic groups in different regions of the population also have differences; (3) RFLP genotypes on the clinical phenotype of diabetes, diabetes and non-diabetic obesity is not the same etiology, but also to see NIDDM with lipid metabolism disorder .