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[目的]建立湖南地区孕晚期女性血浆D-二聚体的参考区间.[方法]选取2014年1月至2016年3月在湖南省妇幼保健院做产前检查的678例单胎晚孕孕妇、418例双胎/多胎晚孕孕妇为研究对象,以同期208例健康非孕妇女为对照,采用全自动生化分析仪使用免疫比浊法测定其D-二聚体浓度.[结果]晚孕孕妇血浆D-二聚体含量明显高于非孕妇女(P<0.05),且双胎/多胎组显著高于同期单胎组(P<0.05).孕晚期女性血浆D-二聚体(D-二聚体单位,DDU)的参考区间:单胎组:28~35周,<3.64μg/mL;36~39周:<6.12μg/mL;40~41周,<6.84μg/mL;双胎/多胎组:28~31周,<6.26μg/mL;32~35周,<7.13μg/mL;36~39周,<8.00μg/mL.[结论]本研究初步建立了湖南省孕晚期妇女免疫比浊法血浆D-二聚体参考区间,适宜全省参考应用.“,”[Objective] To establish reference intervals for D-dimer in women of late pregnancy in Hunan area.[Methods]Six hundred and seventy-eight healthy singleton pregnancy women,418 healthy twins or mul-tiple pregnancy women(≥28 weeks)and 208 healthy non-pregnant women received Physical Examination in the hospital from January 2014 to March 2016 were selected.Automatic biochemical analyzer was used to de-tect the concentration of plasma D-dimer(D-dimer unit,DDU)by immune turbidimetric method.[Results]The plasma levels of D-dimer in third trimester of pregnancy were higher than those of non-pregnant women( P <0.05),the plasma D-dimer level of twins or multiple pregnancy women was significantly higher than that of the singleton pregnancy women in the same period of time(P <0.05).Late pregnant women plasma D-di-mer(D-dimer units,DDU)reference interval:single pregnancy group:28~35 weeks <3.64 μg/mL;36~39 weeks < 6.12 μg/mL;40~41weeks < 6.84 μg/mL;twins /multiple pregnancy group:28~31 weeks <6.26 μg/mL;32~35 weeks < 7.13 μg/mL;36~39 weeks < 8.00 μg/mL.[Conclusion]This study prelimi-narily established the reference interval of plasma D-dimer by immune turbidimetric method in late pregnancy women in Hunan Province,which is suitable for reference in the whole province.