论文部分内容阅读
HLA Ⅱ类基因在发生自身免疫过程中起重要作用。1988年本组血清学分析上海地区44例重症肌无力(MG),发现HLA-DR9频率显著增高,无胸腺瘤的眼肌型患者HLA-B46频率增高。本文报告用多聚酶链反应(PCR)限制片段长度多态性(RFLP)分型技术,从DNA水平分析探讨HLA-DQA1基因与我国MG患者的关联性。
HLA class II genes play an important role in the process of autoimmunity. 1988 serological analysis of 44 cases of myasthenia gravis (MG) in Shanghai, found that HLA-DR9 frequency was significantly higher in patients with non-thymoma ocular HLA-B46 increased frequency. This article reports the use of polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) typing technology, DNA level analysis of HLA-DQA1 gene and MG patients in our country.