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确立诊断幽门螺杆菌(Hp)感染及是否根除的方法很重要。虽有细菌培养和快速尿素酶测定法(RUT),但有时仍难判定,故研究血清胃蛋白酶原含量对Hp根除的诊断价值。 方法:105例消化性溃疡病人,经RUT证实有Hp感染,其中胃溃疡(GU)54例,十二指肠溃疡(DU)51例。男性78例,女性27例,平均年龄53岁±13岁。DU病人口服兰索拉唑30mg,每天1次,共6周;GU病人则服8周,同时服用阿莫西林2.0g/d,共2周。治疗前和根除Hp疗法结束后1个月,所有病人内镜下在胃体大弯、胃窦处取活检标本,作Hp培养、组织病理学检查和RUT,用PCR法检测Hp。治疗后,上述多项指标均转阴性时,定为Hp已根
It is important to establish a diagnosis of Helicobacter pylori (Hp) infection and its eradication. Although bacterial culture and rapid urease assay (RUT), but sometimes still difficult to determine, so the study of serum pepsinogen content of Hp eradication diagnostic value. Methods: 105 patients with peptic ulcer were confirmed Hp infection by RUT, including 54 cases of gastric ulcer (GU) and 51 cases of duodenal ulcer (DU). 78 males and 27 females, with an average age of 53 ± 13 years. DU patients oral lansoprazole 30mg, 1 times a day for 6 weeks; GU patients were served for 8 weeks, while taking amoxicillin 2.0g / d for 2 weeks. Before treatment and 1 month after the end of Hp eradication therapy, all patients underwent endoscopic biopsy at the large curvature of the corpus gland and gastric antrum. Hp culture, histopathological examination and RUT were performed, and Hp was detected by PCR. After treatment, the above indicators were negative when the Hp has been identified as the root