多粘菌素B是一种常用的滴耳药,对革兰氏阴性菌,如绿脓杆菌高度有效,但很多实验表明它有严重的耳毒性。磷霉素具有广谱抗菌活性,对革兰氏阳性和阴性菌均有效,且无毒性作用。有材料表明磷霉素能减轻氨基糖苷类抗生素及顺铀的耳毒性。为研究磷霉素对多粘菌素B耳毒性的影响,用多粘菌素B 0.5ml(5000U/ml)及多粘菌素BO.5ml Polymyxin B is a commonly used ear drop ear medicine, highly effective against Gram-negative bacteria such as Pseudomonas aeruginosa, but many experiments have shown that it has severe ototoxicity. Fosfomycin has a broad spectrum antibacterial activity, effective against Gram-positive and -negative bacteria, and has no toxic effect. Some materials show that fosfomycin can reduce aminoglycoside antibiotics and cis-uracil ototoxicity. To study the effect of fosfomycin on polymyxin B ototoxicity, polymyxin B 0.5 ml (5000 U / ml) and polymyxin B 0.5 ml