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研究表明,纤维蛋白原与凝血、炎症、动脉粥样硬化、心脑血管疾病密切相关。在肾脏疾病中,纤维蛋白原参与了肾小球病变、足细胞损伤及肾小管间质纤维化等。尿纤维蛋白原还可作为早期诊断急性肾损伤的标志物。体外研究发现纤维蛋白原可通过Toll样受体(TLRs)通路介导足细胞释放某些趋化因子和细胞因子。本文主要就纤维蛋白原在肾脏疾病中的作用进展作一总结,为其临床和基础研究奠定基础。
Studies have shown that fibrinogen and coagulation, inflammation, atherosclerosis, cardiovascular disease are closely related. In kidney disease, fibrinogen is involved in glomerular lesions, podocyte injury and tubulointerstitial fibrosis. Urinary fibrinogen can also be used as a early diagnosis of acute kidney injury markers. In vitro studies have shown that fibrinogen can mediate the release of certain chemokines and cytokines by podocytes via the Toll-like receptor (TLRs) pathway. This article mainly summarizes the progress of fibrinogen in kidney disease and lays the foundation for its clinical and basic research.