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本实验以进口硫酸吗啡控释片(B)作对照,采用HPLC测定血中吗啡浓度,在肿瘤患者身上对国产盐酸吗啡控释片(A)进行在稳态血浓度下波动系数及稳态时的浓度曲线下的面积的比较。 8名受试者po 2种吗啡控释片到达稳态血药浓度后各时间点的吗啡浓度差异没有显著意义;A、B两制剂在稳态血浓度下的峰浓度分别为18.94±s 3.23及19.03±s 2.93 ng·ml~(-1),谷浓度分别为6.70±s 1.50及6.73±s 1.34 ng·ml~(-1);波动系数分别为0.87±s 0.12及0.92
In this experiment, morphine controlled release tablets of sulfuric acid (B) as a control, determination of blood concentrations of morphine by HPLC on domestic patients with morphine hydrochloride controlled-release tablets (A) at steady-state blood concentration fluctuations and steady-state Comparison of the area under the concentration curve. There were no significant differences in morphine concentrations at 8 time points between the two groups of morphine controlled-release tablets after steady-state blood concentration was reached. The peak concentrations of A and B at steady-state blood concentrations were 18.94 ± 3.23 And 19.03 ± 2.93 ng · ml -1, the trough concentrations were 6.70 ± s 1.50 and 6.73 ± s 1.34 ng · ml -1, respectively. The coefficient of variation was 0.87 ± s 0.12 and 0.92