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目的：评价阿仑膦酸钠（ａｌｅｎｄｒｏｎａｔｅ，ＡＬＮ）治疗绝经后骨质疏松症的疗效及其与利维爱（ＬＶ）的对比。方法：将Ｗｉｓｔａｒ雌性大鼠６０ 只随机分为正常对照组、去势对照（ＯＶＸ）组、ＡＬＮ 组、ＬＶ 组、ＡＬＮ＋ ＬＶ组（每组１２ 只）。正常对照组做腹腔开关手术，其余４ 组做双侧卵巢切除手术。模型成立后，治疗６ 个月，治疗过程中测量大鼠的全身和腰椎２～４ 的骨密度（ＢＭＤ）、股骨的极限负荷（ＬＬ）和极限挠度（ＬＤ）。结果：经治疗后，ＡＬＮ组、ＬＶ组和ＡＬＮ＋ ＬＶ 组大鼠的全身骨密度较治疗前分别增加４．４９％ ，６．１２％ ，６．７４％ ，较同期ＯＶＸ组分别增加１３．４１％ ，１５．８５％ ，１５．８５％ ；腰椎２～４ 的ＢＭＤ 较治疗前分别增加４．９８％ ，７．７３％ ，７．７０％ ，较同期ＯＶＸ 组分别增加１４．２９％ ，１６．７５％ ，１７．２４％ 。ＡＬＮ 组、ＬＶ 组和ＡＬＮ＋ ＬＶ 组大鼠股骨的极限强度和极限挠度较同期ＯＶＸ组也明显恢复（Ｐ＜ ０．０５），取得了良好的疗效。ＡＬＮ 组的疗效好于ＬＶ 组。结论：ＡＬＮ 是一种对治疗绝经后骨质疏松症有良好疗效的药物，其疗效优于ＬＶ，联合应用疗效更好
AIM: To evaluate the efficacy of alendronate (ALN) in the treatment of postmenopausal osteoporosis and its comparison with levofloxacin (LV). Methods: Sixty female Wistar rats were randomly divided into normal control group, OVX group, ALN group, LV group and ALN + LV group (12 rats in each group). Normal control group to do abdominal switch surgery, and the remaining 4 groups to do bilateral ovariectomy. The model was established and treated for 6 months. Body mass and lumbar spine 2 to 4 bone mineral density (BMD), femur ultimate load (LL) and ultimate deformability (LD) were measured during treatment. Results: After treatment, the total body BMD in ALN group, LV group and ALN + LV group increased by 4.49%, 6.12% and 6.74% respectively compared with that before treatment, which was 13.41 %, 15.85% and 15.85% respectively. The BMD of 2 ~ 4 in lumbar spine increased by 4.98%, 7.73% and 7.70% respectively compared with before treatment, which was 14.29% .75%, 17.24%. Compared with the OVX group, the ultimate strength and the ultimate deflection of ALN, LV and ALN + LV groups significantly recovered (P <0.05), and achieved good results. ALN group is better than LV group. CONCLUSIONS: ALN is a good drug for the treatment of postmenopausal osteoporosis. Its efficacy is better than that of LV, and the combination effect is better