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目的探讨脂蛋白相关磷脂酶A_2(Lp-PLA_2)对行直接经皮冠状动脉介入治疗(PCI)的急性ST段抬高性心肌梗死(STEMI)患者预后的预测价值。方法连续入选2014年6月至2015年6月在河北省涿州市医院心内科住院治疗的首次急性心肌梗死患者共220例。入院根据PCI术前检测Lp-PLA_2水平分为高、低水平两组,随访6个月,观察住院期间及随访期间心血管事件发生情况。结果高Lp-PLA_2组在前壁心肌梗死、心功能killip≥Ⅱ分级比例、血肌酐(Cr)水平及冠脉病变支数高于低Lp-PLA_2组,左室射血分数(LVEF)明显低于低Lp-PLA_2组,6个月内预后比较有统计学意义(p<0.05)。结论脂蛋白相关磷脂酶A_2对行直接PCI的急性STEMI患者6个月内发生心血管事件的预测有一定的价值。
Objective To investigate the predictive value of lipoprotein-associated phospholipase A 2 (Lp-PLA 2) in the prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing direct percutaneous coronary intervention (PCI). Methods A total of 220 patients with acute myocardial infarction were enrolled in our hospital from June 2014 to June 2015 in our department of cardiology, Danzhou City, Hebei Province. Admission based on the level of Lp-PLA_2 before PCI was divided into high and low levels of two groups, followed up for 6 months to observe the incidence of cardiovascular events during hospitalization and follow-up. Results In Lp-PLA 2 group, the myocardial infarction rate, the killip Ⅱ score, the serum creatinine (Cr) level and the number of coronary lesions were significantly higher in the Lp-PLA 2 group than those in the Lp-PLA 2 group In low Lp-PLA 2 group, the prognosis was statistically significant within 6 months (p <0.05). Conclusions Lipoprotein-associated phospholipase A 2 is of value in predicting cardiovascular events within 6 months in patients with acute STEMI who underwent direct PCI.