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为了探讨某些高危妊娠与人巨细胞病毒(HCMV)感染之间的关系,本研究应用酶联免疫法(ELISA)与核酸杂交技术(生物素标记探针和洋地黄标记探针)对195例正常妊娠的孕妇和144例有某些异常妊娠情况孕妇本人血、部分新生儿脐血和尿进行了 CMV-1gG、IgM、CMV-DNA 检测,并比较它们的阳性率。结果表明高危妊娠组母血(CMV-IgG、IgM 和 CMV-DNA 阳性率、脐血 IgM 的阳性率以及新生儿尿 CMV-DNA 阳性率均较正常妊娠组高,具有显著性(P<0.05)或极显著性差异(P<0.01).从而证实某些高危妊娠的发生与 HCMV 感染密切相关。
In order to investigate the relationship between HCMV infection and some high-risk pregnancies, we used enzyme-linked immunosorbent assay (ELISA) and nucleic acid hybridization (biotin-labeled probe and digitalis labeled probe) CMV-1gG, IgM, CMV-DNA were detected in pregnant women and 144 pregnant women with some abnormal pregnancy, some newborn umbilical cord blood and urine, and compared their positive rate. The results showed that the positive rate of CMV-IgG, IgM and CMV-DNA, the positive rate of IgM in cord blood and the positive rate of CMV-DNA in neonatal urine in high risk pregnancy group were significantly higher than those in normal pregnancy group (P <0.05) Or very significant difference (P <0.01), thus confirming the occurrence of some high-risk pregnancies and HCMV infection are closely related.