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Objective:To study the effect ofYinxieling decoction onPASI,TNF-α andIL-8 in patients with psoriasis vulgaris. Methods:A total of120 cases of psoriasis vulgaris were divided into4 groups according to syndrome differentiation ofTCM and randomized controlled method: wind heat syndrome group(groupA), blood stasis syndrome group(groupB), blood dryness syndrome group (groupC) and control group(groupD)(n=30 per group).Patients in observation groups were treated withYinxieling decoction, while patients in control group were treated by placebo for8 weeks. Levels ofTNF-α andIL-8 were determined before treatment,4 and8 weeks after treatment. psoriasis area and severity index score was also performed before and after treatment.Results:psoriasis area and severity index score and serum level ofTNF-α,IL-8 were significantly decreased in all groups.The decrease in three observation groups was more significant(P<0.05 orP<0.01), and the decrease in wind heat syndrome group was the most significant(P<0.01). psoriasis area and severity index was positively correlated withTNF-α andIL-8, respectively (P<0.05).Conclusions:Yinxieling decoction has therapeutical effect on psoriasis vulgaris via regulatingTNF-α andIL-8.