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目的探讨低压缺氧条件下苯妥英钠(DPH)抗缺氧及耐疲劳作用的生化机制。方法 Wistar大鼠72只,每组12只。用药组分低压舱上升至7.5 km 1 h,7.5 km 2 h及地面3组,每组各设对照组。用药组腹腔注射DPH 40 mg/kg体重,对照组注射等量的生理盐水。结果用药组在低压缺氧条件下脑含水量、Na~+及K~+含量、Na~+,K~+-ATP酶活性和丙二醛(MDA)含量与地面组比较均无显著性差异(除7.5 km 1 h组MDA含量升高,P<0.01),而对照组上述指标均有不同程度的变化(P<0.05或P<0.01)。结论 DPH对低压性脑缺氧具有保护作用。
Objective To investigate the biochemical mechanisms of hypoxia and fatigue resistance of phenytoin sodium (DPH) under hypobaric hypoxia. Methods 72 Wistar rats, 12 rats in each group. The components of low pressure cabin increased to 7.5 km 1 h, 7.5 km 2 h and 3 groups on the ground, with control group in each group. The treatment group was injected intraperitoneally with DPH 40 mg / kg body weight, while the control group was injected with the same amount of saline. Results The brain water content, Na ~ + and K ~ + contents, Na ~ +, K ~ + -ATPase activity and malondialdehyde (MDA) content in the hypoxia and hypoxia groups were not significantly different from those in the ground group (Except for 7.5 km 1 h, the content of MDA increased, P <0.01), while the above indexes of the control group all had different degrees of change (P <0.05 or P <0.01). Conclusion DPH has a protective effect on hypobaric hypoxic.