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随着糖尿病患者数量急剧增加,女性糖尿病患者不孕不育及生殖内分泌异常疾病的问题日益严重。研究表明糖尿病患者体内的高血糖水平,异常的胰岛素浓度和瘦素浓度能够阻碍下丘脑和垂体对卵巢的调控或直接作用于卵巢影响卵泡的正常发育和卵母细胞的成熟导致排卵障碍,损伤卵巢的正常功能进而影响妊娠和内分泌稳态。本文结合最新的研究进展,深入讨论了糖尿病对卵巢卵泡发育影响的具体机制,为相关疾病的治疗提供新的思路和见解。
With the dramatic increase in the number of diabetic patients, the problem of infertility and reproductive and endocrine abnormalities in women with diabetes is worsening. Studies have shown that hyperglycemia, abnormal insulin concentrations and leptin concentrations in diabetic patients can hinder the hypothalamus and pituitary regulation of the ovary or directly affect the ovarian normal follicular development and oocyte maturation lead to ovulation disorders, damage the ovary The normal function and thus affect the pregnancy and endocrine homeostasis. In this paper, with the latest research progress, in-depth discussion of diabetes on ovarian follicular development of specific mechanisms for the treatment of related diseases provide new ideas and insights.