目的 :定位一个常染色体显性遗传无综合征耳聋家系的致病基因。方法 :采用已报道的 2 2个常染色体显性遗传性耳聋位点的筛选微卫星标记物对该家系进行连锁分析。结果 :各位点连锁分析所得的LOD值均小于 1,显示该家系致聋基因与这 2 2个位点均不连锁。结论 :该家系的耳聋发病很可能由一新基因所致。 Objective: To locate a causative gene of an autosomal dominant inheritance-free syndrome deafness pedigree. Methods: We have used the reported microsatellite markers of 22 autosomal dominant deafness loci to analyze the pedigree. Results: The LOD values ​​of all loci were less than 1, indicating that the deafness gene in this family was not linked with these two loci. Conclusion: The incidence of deafness in this pedigree is likely to be caused by a new gene.