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目的:观察噻托溴铵联合运动训练对中重度慢性阻塞性肺疾病(COPD)稳定期患者BODE指数的影响。方法:80例中重度COPD稳定期患者按就诊时间顺序分为观察组及对照组各40例。观察组在常规治疗基础上给予吸入噻托溴铵联合运动训练,对照组仅给予常规治疗,观察期为6个月。比较两组患者BODE指数。结果:6个月后观察组BODE指数分值较对照组明显下降(P<0.05),其中6 min步行距离、肺功能指标等均较对照组有明显改善(P<0.05);而两组体重指数、呼吸困难量表比较,差异无统计学意义(P>0.05)。结论:噻托溴铵联合运动训练能明显改善中重度COPD稳定期患者BODE指数及预后。
Objective: To observe the effects of tiotropium on BODE in stable COPD patients with moderate to severe chronic obstructive pulmonary disease (COPD). Methods: Eighty patients with stable COPD were divided into observation group and control group according to the time sequence of treatment. The observation group was given inhaled tiotropium on the basis of routine treatment, and the control group was given routine treatment only for 6 months. BODE index was compared between the two groups. Results: After 6 months, the score of BODE in the observation group was significantly lower than that in the control group (P <0.05), and the 6-minute walk distance and pulmonary function indexes were significantly improved compared with the control group (P <0.05) Index, dyspnea scale comparison, the difference was not statistically significant (P> 0.05). Conclusion: Tiotropium combined exercise training can obviously improve the BODE index and prognosis of stable COPD patients.