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目的探讨血管内皮生长因子(VEGF)评估急性心肌梗死(AMI)的价值。方法测定AMI患者(A组,61例)和心绞痛患者(B组,20例)外周血VEGF表达,分析VEGF表达差异的临床意义。结果 A组外周血VEGF水平高于B组[(73.44±17.09)ng/ml vs.(58.79±36.43)ng/ml)](P<0.05)。A组患者不同罪犯血管(前降支、回旋支、右冠脉)患者的外周血VEGF表达差异有统计学意义(P<0.05)。随访18个月后,A组低VEGF(<50ng/ml)患者的主要心血管不良事件(MACE)发生率高于高VEGF(≥50ng/ml)者(68.4%vs.22.2%)(P<0.05)。结论在AMI早期阶段,外周血中VEGF有重要的生理作用;AMI早期低VEGF水平可作为临床上MACE的预测指标。
Objective To investigate the value of vascular endothelial growth factor (VEGF) in evaluating acute myocardial infarction (AMI). Methods The expression of VEGF in peripheral blood of AMI patients (group A, 61 cases) and angina pectoris patients (group B, 20 cases) was determined, and the clinical significance of VEGF expression was analyzed. Results The level of VEGF in group A was higher than that in group B [(73.44 ± 17.09) ng / ml vs. (58.79 ± 36.43) ng / ml)] (P <0.05). The VEGF expression in peripheral blood of patients with different criminals (descending branch, circumflex artery, right coronary artery) in group A was significantly different (P <0.05). After 18 months of follow-up, the incidence of major adverse cardiovascular events (MACE) in patients with low VEGF (<50 ng / ml) in group A was significantly higher than those in patients with high VEGF (≥50 ng / ml) (68.4% vs.22.2% 0.05). Conclusion In the early stage of AMI, VEGF in peripheral blood has an important physiological function. Early low VEGF levels in AMI can be used as predictors of clinical MACE.