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本文报道一对夫妇同时发生胰腺癌。妻子年64岁,1977年1月主诉上腹痛并放射到背部6周,伴乏力、纳果、恶心、呕吐;3周来有黄疸、粪色白和尿色深。体检发现巩膜轻度黄染,腹柔,肝肋下3指,未触及腹块,无腹水。尿胆红素+,尿胆元++++,尿糖-。血胆红素58μmol/l(正常为20μmol/1),碱性磷酸酶480U/l(正常100～125U/l),谷丙转氨酶96U/l(正常为0～30U/l),血淀粉酶580U/l(正常为10～300U/l)。腹部超声及经皮肝穿刺胆管造影(PTC)显示肝内和肝外胆管显著扩张,胆总管远端2cm肿瘤浸润性狭窄。手术证实巨大的胰头肿块已不能切除。术后4个月出现严重背痛、腹水和贫血,全身情况继续恶化而死亡,未能作尸检。其丈夫自1977年7月起出现上腹痛且放射到背部,
This article reports a couple with pancreatic cancer. Her wife was 64 years old. In January 1977, she complained of upper abdominal pain and radiated to the back for 6 weeks with fatigue, nago, nausea, and vomiting. She had jaundice, fecal whiteness, and dark urine for 3 weeks. Physical examination revealed mild sclerosis of yellow sclera, abdomen soft, liver ribs with 3 fingers, no palpable abdominal mass, no ascites. Urine bilirubin +, urinary bladder +++, urine sugar -. Blood bilirubin 58μmol/l (normally 20μmol/1), alkaline phosphatase 480U/l (normal 100～125U/l), alanine aminotransferase 96U/l (normal 0～30U/l), blood amylase 580U/l (Normally 10~300U/l). Abdominal ultrasound and percutaneous transhepatic cholangiopancreatography (PTC) showed significant expansion of the intrahepatic and extrahepatic bile ducts, and infiltrative stenosis of the distal 2 cm of the common bile duct. Surgery confirmed that the huge pancreatic head mass has not been removed. Severe back pain, ascites, and anemia occurred 4 months after the operation. The general condition continued to deteriorate and died, and no autopsy could be performed. Her husband had abdominal pain and radiation to the back since July 1977.