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由于目前所用的乙型肝炎疫苗接种方案费用高,我们观察比较了现行接种程序(用Heptavax—B疫苗20微克HBsAg肌肉内接种,接种日程为首次接种,30天和180天)和具有潜在经济价值的小剂量接种程序(2微克HBsAg皮内接种法,接种日程同上)。本试验接种观察了50例血清阴性的健康卫生工作者,用双盲法并设安慰剂对照组,以评价两种接种途径的免疫性及反应原性。每一接种对象同时用肌肉和皮内接种法,而疫苗使用的途径为
Due to the high cost of the currently used hepatitis B vaccination program, we observed and compared the current vaccination program (intramuscular inoculation of 20 micrograms of HBsAg with Heptavax-B vaccine, vaccination schedules for first vaccination, 30 days and 180 days) and potential economic value Dose vaccination program (2 μg HBsAg intradermal inoculation, vaccination schedule as above). Inoculation observed in this study 50 cases of seronegative health workers, double-blind and placebo-control group to evaluate the immunization and response of the two routes of immunization. Each inoculated with both intramuscular and intradermal inoculation method, and the vaccine is used