多发性内分泌性腺瘤病(MEA)是遗传性疾病,有肿瘤或几种内分泌腺增生。患Ⅰ型MEA时,脑垂体、甲状旁腺、胰岛和肾上腺最常受累。约90％的本病患者有甲旁亢。一些报告已叙述,甲旁亢作为家族性Ⅰ型MEA的一部分一般无症状,并具有令人惊奇的轻微临床病程。另一方面,Boey等发现,Ⅰ型MEA的甲旁亢患者和孤立的甲旁亢患者之间,临床症状和并发症无区别。为了确定作为MEAⅠ型的甲旁亢是否是甲 Multiple endocrine adenomatosis (MEA) is a hereditary disease with a tumor or several endocrine gland hyperplasias. With Type I MEA, pituitary, parathyroid, islets, and adrenal glands are most often involved. About 90% of patients with this disease have parathyroidism. Some reports have stated that parathyroid hormone is generally asymptomatic as part of a familial type I MEA and has a surprisingly mild clinical course. On the other hand, Boey et al. found no difference in clinical symptoms and complications between patients with parametrial paralysis and isolated hyperparathyroidism in type I MEA. In order to determine if a melatonin that is MEAI type is A