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目的 探讨多药耐药基因(MDR_1)在肿瘤患者外周血的表达,观察其与化学药物治疗的相关性。方法 采用逆转录—多聚酶链反应。结果 106例肿瘤患者外周血MDR_1阳性率为31/106(28％),其中肺癌15/47(32％),乳腺癌10/33(30％)、淋巴瘤5/20(25％)、卵巢癌1/6(17％)。化疗疗效随着MDR_1水平表达阳性强度的升高而降低。结论 我们的研究结果可以初步看出,肿瘤外周血MDR_1检出率及MDR_1表达水平与病人临床接受化疗药物治疗密切相关,可望为临床提供一个有意义的指标临床医生可以根据每个病人MDR_1的表达情况,合理地制定化疗方案。
Objective To investigate the expression of multidrug resistance gene (MDR_1) in peripheral blood of patients with cancer and observe its correlation with chemotherapy. Methods Reverse transcription-polymerase chain reaction was used. Results The positive rate of MDR-1 in peripheral blood of 106 patients with tumor was 31/106 (28%), including 15/47 (32%) of lung cancer, 10/33 (30%) of breast cancer, 5/20 (25%) of lymphoma, and ovary. Cancer 1/6 (17%). The efficacy of chemotherapy decreased as the positive expression level of MDR1 increased. Conclusion Our results can be seen initially that the detection rate of MDR_1 in peripheral blood and the expression level of MDR_1 are closely related to the clinical treatment of patients receiving chemotherapeutic drugs, and it is expected to provide a meaningful clinical indicator for clinicians. According to each patient MDR_1 Expression of the situation, the rational formulation of chemotherapy programs.