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高迁移率蛋白1（HMGB1）是高迁移率蛋白家族成员之一，其生理作用广泛，参与细胞核内DNA重组、染色质结构稳定、基因转录调控、细胞修复、分化等生命活动，是细胞及生物体存活的关键。 HMGB1相关信号通路作为晚期炎性介质信号，参与了缺血／再灌注损伤、急性肾损伤、慢性肾脏病、狼疮性肾炎等肾脏病。“,”High mobility group box-1 protein(HGMB1) is a member of high mobility group box-1 pro-tein family that plays comprehensive physical roles such as genetic recombination in nucleus ,chromatin struc-ture stability,gene transcription regulation,cell repair,differentiation,which is the key of the cell and organ-ism survival.HGMB1-associated pathway, as late inflammatory mediators, plays an important role in the kideny diseases including ischemia-reperfusion injury,acute kidney injury,chronic kidney disease,and lupus nephritis.