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目的：探讨肿瘤相关抗原ＣＡ１５－３在胃癌中的表达和意义。方法：应用免疫组织化学ＳＰ法检测５５例胃癌，癌旁组织，正常胃粘膜和３０例胃溃疡组织中ＣＡ１５－３的表达情况。结果：５５例胃癌阳性表达者４３例（７８．２％）。其中胞浆胞膜均阳性者３０例（６９．８％），而胞膜阳性１３例（３０．２％）。５５例癌旁组织阳性表达者２例（３．６％），仅为胞膜阳性，溃疡及正常胃粘膜均为阴性。ＣＡ１５－３阳性表达及胞浆阳性定位与组织学分型有关（Ｐ＜０．０１），与胃癌进展，浸润深度，淋巴结转移无关（Ｐ＞０．０５），结论：ＣＡ１５－３阳性表达可能是胃癌变细胞的标志之一。
Objective: To investigate the expression and significance of tumor-associated antigen CA15-3 in gastric cancer. Methods: Immunohistochemical SP method was used to detect the expression of CA15-3 in 55 cases of gastric cancer, adjacent tissues, normal gastric mucosa and 30 cases of gastric ulcer. RESULTS: Forty-five cases of gastric cancer positive expression were found in 43 cases (78.2%). Among them, 30 cases (69.8%) were positive for cytoplasmic membranes and 13 cases (30.2%) were positive for membranes. 55 cases of paracancerous tissue positive expression in 2 cases (3.6%), only membrane-positive, ulcers and normal gastric mucosa were negative. The positive expression of CA15-3 and positive cytoplasmic location were related to histological type (P<0.01), but not to the progression, infiltration depth and lymph node metastasis of gastric cancer (P>0.05). Conclusion: The positive expression of CA15-3 may be One of the hallmarks of gastric cancer.