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目的：：测定4家国内企业阿莫西林胶囊在4种溶出介质中的溶出曲线,并与进口阿莫西林胶囊的溶出曲线进行比较.方法：以 pH1．2盐酸溶液、pH4．0醋酸盐缓冲液、水、pH6．8磷酸盐溶液为溶出介质各900mL.采用篮法,转速100r?min－1,采用紫外分光光度法在9个不同的时间点测定溶出量绘制溶出曲线,并用 f2因子法进行比较分析.结果：国内生产的阿莫西林胶囊在4种溶出介质中的溶出曲线与进口阿莫西林胶囊完全相似.结论：我国阿莫西林胶囊的质量与进口阿莫西林胶囊差异较小.在一定程度上可以用国产阿莫西林胶囊替代进口阿莫西林胶囊.“,”Objective:To determine the dissolution curves of amoxicillin capsules of 4 domestic pharmaceutical manufactures in four dissolution mediums,and compared with the dissolution profiles of imported amoxicillin capsules.Method:pH1 .2 hydrochloric acid solution ,pH4.0 acetate buffer,water,pH6.8 phosphate solution was selected as the dissolution medium each 900mL,The basket method was a-dopted at 100r?min-1 ,the dissolution curves were determined with ultraviolet spectrophotometry(UV)in 9 different time points,and comparatively analyzed by the f2 factor method.Results:The dissolution curves of 4 domestic produced amoxicillin capsules in four dissolu-tion mediums were similar to imported product in all 4 dissolution mediums.Conclusion:There is little difference between the quality of do-mestic amoxicillin capsules and imported amoxicillin capsules .It is advised that domestic amoxicillin capsules should be substituted as im-ported amoxicillin capsules in some degree.