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应用免疫组化及图像分析技术观察１４０例各组织学类型胃癌中生长抑素（ＳＳ）的表达，并随访其中１２７例。３６例胃癌中检出ＳＳ阳性细胞（２５．７％）。ＳＳ的表达与胃癌组织学类型、分化及淋巴结转移无明显关系，但与预后有明显关系。ＳＳ阳性胃癌组预后较好，较ＳＳ阴性胃癌组生存期长（Ｐ＜０．０１）。ＤＮＡ图像分析结果显示，与ＳＳ阴性胃癌组相比，ＳＳ阳性胃癌组的３～４Ｃ细胞与５Ｃ细胞所占比例较大，＞５Ｃ细胞所占比例较小。上述结果提示ＳＳ作为抑制因子不仅可抑制胃癌细胞的生长，而且含有ＳＳ细胞的胃癌患者生存期长，预后较好。推测胃癌中分泌的ＳＳ和其自身膜表达受体结合，抑制自身生长。胃癌中ＳＳ与ＳＳ受体相互间的关系及对胃癌的影响尚须进一步研究。
Immunohistochemistry and image analysis techniques were used to observe the expression of somatostatin (SS) in 140 cases of histological types of gastric cancer, and 127 of them were followed up. SS-positive cells were detected in 36 cases of gastric cancer (25.7%). The expression of SS was not significantly related to the histological type, differentiation and lymph node metastasis of gastric cancer, but had a significant relationship with prognosis. The SS-positive gastric cancer group had a better prognosis and had a longer survival period than the SS-negative gastric cancer group (P<0.01). DNA image analysis showed that compared with the SS-negative gastric cancer group, the ratio of 3 to 4C cells and 5C cells in the SS-positive gastric cancer group was larger, and the proportion of >5C cells was smaller. These results suggest that SS as an inhibitor not only inhibits the growth of gastric cancer cells, but also that patients with gastric cancer containing SS cells have a long survival period and a good prognosis. It is presumed that SS secreted in gastric cancer expresses receptor binding with its own membrane and inhibits its own growth. The relationship between SS and SS receptors in gastric cancer and its effect on gastric cancer still need further study.