【摘 要】
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With the development of in vivo imaging techniques, it was discovered early in this century that microglia are highly dynamic even in the resting state [1].Howe
【机 构】
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Institute of Life Science, Nanchang University, Nanchang 330031, China
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With the development of in vivo imaging techniques, it was discovered early in this century that microglia are highly dynamic even in the resting state [1].However, for over a decade, little has been learned about how the dynamic microglial motility is regulated, particularly in physiological and awake conditions [2].Two recent studies have made a breakthrough in this regard, showing that the motility of microglial processes is regulated by a shift in the state of neuronal activity, and the neurotransmitter norepinephrine (NE) is one of the key neuronal signal mediators through acting on microglial β2 receptors [3].Now, a new study has further revealed that Ca2+ microdomain signaling in microglial processes is an exquisite sensor for neuronal activity shifts, and this is associated with process extension/outgrowth (Fig.1).
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